Sleep and behavioral disturbances induced by epilepsy: Protective effect of Gabapentin

Numerous sleep disturbances induced by nocturnal epilepsy have been reported. Gabapentin (GBP) is used as an adjuvant or a monotherapeutic treatment it induces significant improvement in patients with partial secondaryly widespread focal seizures. In experimental animal models of pentilenetetrazole (PTZ), GBP protects against the generated The objective this work was to investigate its effectiveness protecting motor and caused Polygraphic studies were conducted male wistar rats, separated into 4 groups. After administration saline solution, check record carried out on each group. Subsequently, one group received 50 mg/kg PTZ, while other three groups 15, 30 60 GBP, minutes prior PTZ administration. electrophysiological behavioral manifestations characterizing seizures observed. addition, surveillance states significantly altered, increasing amount wakefulness, inhibited over period time. doses tended inhibit presence abnormal behaviors, facilitating sleep.